new deadly human-to-human-transmissible coronavirus emerges out of China
POSTED BY: 1KIKI
UPDATED: Tuesday, May 5, 2026 22:21
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Quote:GOOD NEWS!
Originally posted by 1KIKI:
Report: Covid-19 patients recovering quickly after getting experimental drug remdesivir
https://www.statnews.com/]
But China dropped out of the study.
Quote:
Gilead's stock drops after China halts second remdesivir trial
https://www.marketwatch.com/story/gileads-stock-drops-after-china-halt
s-second-remdesivir-trial-2020-04-15 (April 15)
I wonder why? It's probably an IP thing. Originally they said they wanted to patent remdesivir themselves.
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Pity would be no more,
If we did not MAKE men poor - William Blake
#WEARAMASK
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Reading through a number of links, here's some basic info:
I thought Remdesivir looked like a nucleotide analogue (if pressed I wouldn't have had a guess as to which one), and indeed, it's an analogue for adenosine. The shape is one that interacts with coronavirus RNA polymerase enzymes that replicate the RNA genetic code. (Other viruses have different enzymes that do the same thing, that don't interact with Remdesivir, so it's ineffective against them. It was initially trialed as an Ebola drug. When that failed, it was retasked to SARS/ MERS where it showed promise in animal studies.) Once Remdesivir is inserted into the RNA instead of adenosine, replication stops.
Remdesivir has to be given early enough, before cytokine storm takes over. Once cytokine storm happens, it becomes the primary pathology, not SARS-COV-2.
The initial ad hoc use in China included patients well into pathology, beyond the reach of Remdesivir. For the recent formal trial, China didn't have enough patients to participate.
https://www.statnews.com/2020/03/16/remdesivir-surges-ahead-against-co
ronavirus/
https://www.statnews.com/2020/04/16/early-peek-at-data-on-gilead-coron
avirus-drug-suggests-patients-are-responding-to-treatment/
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Quote:I don't see how China could patent it since Gilead, NIH, UNC Chapel Hill, and others did the development work according to my links. Let me post them above if you want to follow up.
Originally posted by SIGNYM:Quote:GOOD NEWS!
Originally posted by 1KIKI:
Report: Covid-19 patients recovering quickly after getting experimental drug remdesivir
https://www.statnews.com/]
But China dropped out of the study.
Quote:
Gilead's stock drops after China halts second remdesivir trial
https://www.marketwatch.com/story/gileads-stock-drops-after-china-halt
s-second-remdesivir-trial-2020-04-15 (April 15)
I wonder why? It's probably an IP thing. Originally they said they wanted to patent remdesivir themselves.
-----------
Pity would be no more,
If we did not MAKE men poor - William Blake
#WEARAMASK
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A lot of basic drug development (and other research) is actually subcontracted to Chinese labs. And China has a way of making outside firms share their IP.
Quote:Applies only in China? Would this be like a license?
China Wants to Patent Gilead’s Experimental Coronavirus Drug
Bloomberg News
February 5, 2020
Chinese researchers have applied for a national patent
Quote:Patents are linked to applications and uses, not just to the item and technology. If you come up with a novel way to use a paperclip, I think you can patent it.
on an experimental Gilead Sciences Inc. drug that they believe might fight the novel coronavirus.
The Wuhan Institute of Virology -- based in the Chinese city at the center of the epidemic -- has applied for a patent in China for the use of the antiviral drug, known as remdesivir, in treating the ailment.
Quote:
The application was made on Jan. 21 together with a military academy, according to a Feb. 4 statement on the institute’s website.
Large areas of China have been paralyzed by the coronavirus, and the move signals a desire to speed development of one of the most promising potential treatments. Beijing has moved aggressively to contain the infection that has killed almost 500 people and sickened nearly 25,000. If the application succeeds, Gilead would need to get Chinese patent owners on board in sales of the drug for treating coronavirus infections outside China.
“The good thing in having a patent is that it would lead to cross-licensing situations that give China more bargaining chips in negotiating the licensing fee with Gilead,” said Wang Yanyu, a senior partner at AllBright Law Offices in Beijing.
The move may revive longstanding concerns about China’s respect for intellectual property rights. The country has made strides in the pharmaceutical space in recent years as it works to nurture a domestic industry based on innovative drugs.
It’s not clear if or when China’s intellectual property authorities will approve the institute’s application. The patent filing will need to prove that the drug works on this coronavirus strain, 2019-nCoV, in a way that’s different from its effect on other viruses in the same category.
Filing of the patent application by a stakeholder in China, however, makes sense, according to Wang. “Most of the patients are here, rather than in the U.S., which makes it unlikely that Gilead will do all these tests,” he said.
Coronavirus Lurking in Feces May Reveal Hidden Risk of Spread
While Gilead’s experimental drug isn’t licensed or approved anywhere in the world, it is being rushed into trials in China on coronavirus patients after showing early signs of being highly effective. It may go into clinical trials in China as early as next week in patients with moderate and severe symptoms of the pathogen, said Merdad Parsey, Gilead’s chief medical officer.
Chinese scientists have found Gilead’s remdesivir, and chloroquine, an 80-year-old malaria drug, “highly effective” in laboratory studies at thwarting the coronavirus, they said Tuesday in a paper in the journal Cell Research. The two drugs’ efficacy on humans required further clinical tests, the institute said in its statement.
Wants Access
China is capable of manufacturing chloroquine and now wants access to remdesivir.
The decision, however, to seek a patent instead of invoking the heavy-handed “compulsory license” option that lets nations override drug patents in national emergencies, underscores the delicate balancing act before China as it signals commitment toward intellectual property rights alongside curbing the virus outbreak.
“The fact that they have applied for a patent means there’s growing awareness about this in the country,” said Wang. “The government is compelled to avoid using the compulsory license because it has been making efforts to show China respects intellectual property rights and the abuse of compulsory licensing will draw international criticism.”
Gilead will retain the global rights to market the antiviral medication,NOTIFY: Y | REPLY | REPLY WITH QUOTE | PERMALINK | TOP | HOME
Wow.
I had no idea all that was going on. That's QUITE the eye opener! THANKS.
And yeah, there's a lot there I don't understand.
But this might be the death knell for Chinese patent application: "The patent filing will need to prove that the drug works on this coronavirus strain, 2019-nCoV, in a way that’s different from its effect on other viruses in the same category." Well, 2019-nCoV is now SARS-COV-2, in the SARS virus family. It seems to me that would put it in the same 'category' of virus as SARS-COV, the second use for remdesivir as researched by Gilead et al (after its first use for Ebola).
So maybe China is just dropping out of international studies because it sees no need to help international efforts along with a drug it can't patent? Or maybe Gilead is rushing along with clinical trials to get an international patent in first because there's a real chance China could be granted its own?
Too complicated for me. I can't imagine how they might be thinking of this.
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There hasn't been a single thing produced out of China that had a copyright or patent that China respected.
If China were to patent a drug, just simply reverse-engineer it and sell it at generic WalMart prices for $3 for your script.
Goose meet gander. Fuck China.
Do Right, Be Right. :)
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Quote:
Originally posted by SIGNYM:
I don't know what happened 3-5 weeks ago (Spring Break? Mardi Gras?), but the USA as a whole reported 4,591 new deaths in one day; well more than twice the usual daily number of heart attacks, which is the usual top cause of death (~2000), and almost twice the record number of the day before (2569)
For those of you who are counting, that would be 1.7 MILLION deaths per year.
No it wouldn't.
By the end of the year everybody might have already caught it and either gotten over it or died. Hell... that might already be the case now, and a month from now it falls to nothing and we never see any large numbers again.
The only way that this would become a long-term 1.7 Million deaths every year is if there is any truth at all to the possibility of re-infection AND unlike any other virus out there it infects people at the same rate all year round and doesn't drastically change its behavior based off of the season.
And your daily change isn't taking into account that TPTB just changed the rules to allow a ton of deaths that aren't even verified to be related to The Coomph at all to be confirmed Coomph kills. New York has been throwing thousands of dead bodies on that pile, completely destroying any credibility of death counts we may have had before the change.
Do Right, Be Right. :)
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How little you know, Kevin.
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How little any of us know, Karen.
Do Right, Be Right. :)
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Quote:
Originally posted by SIGNYM:
I don't know what happened 3-5 weeks ago (Spring Break? Mardi Gras?), but the USA as a whole reported 4,591 new deaths in one day; well more than twice the usual daily number of heart attacks, which is the usual top cause of death (~2000), and almost twice the record number of the day before (2569)
Quote:I went back to the data I've been casually keeping. Part of that data is just recording states' cases and deaths when the states have more than 3,000 cases.
For those of you who are counting, that would be 1.7 MILLION deaths per year. Mostly in the NYC, NJ, and MICHIGAN area (the state where people are just dying to get back to work).
Altho NYC just went back and reclassified ~4000 deaths posthumously, those deaths were NOT included in the figure.
So, seriously, what happened? Young adults came home from Spring Break/Mardis Gras and gave it to mom and dad, or grandma and grandpa?
-----------
Pity would be no more,
If we did not MAKE men poor - William Blake
#WEARAMASK
I spanned across 2 days in terms of calculating increased deaths, because I didn't want to miss any big increases by picking bad times. It looks like NYS accounts for nearly the entire large increase, at ~5100 deaths over 2 days. In general, NYS has been recently tracking 500 - 700 deaths per day. Some of the others had a small bump up in their day-on-day increases, but nothing that can't be accounted for by being on the wrong side of the curve.
Deaths between April 17, 2020, 18:03 GMT - April 15, 2020, 17:29 GMT
New York 5150
New Jersey 684
Massachusetts 288
Pennsylvania 141
Michigan 325
California 183
Illinois 204
Florida 95
Louisiana 110
Texas 64
Georgia 98
Connecticut 300
Maryland 76
Washington 36
Indiana 83
Colorado 45
Ohio 65
Virginia 36
Tennessee 17
North Carolina 41
Missouri 21
Arizona 27
Alabama 25
Rhode Island 31
South Carolina 12
Wisconsin 27
Mississippi 7
Nevada 12
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