Real World Event Discussions

new deadly human-to-human-transmissible coronavirus emerges out of China

POSTED BY: 1KIKI
UPDATED: Tuesday, May 5, 2026 22:21
VIEWED: 203741
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Sunday, August 22, 2021 7:50 AM

It sounds like they're having a harder time wrangling up fake Delta death numbers than they are finding polls that keep Biden*'s job approval above water.

But then again without flu deaths to blame in the middle of summer, it makes sense that it's harder for them to do so now.



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Vaccinated People: "You need to get muh vaccination shots that don't work because I got muh vaccination shots that don't work and I'm afraid of people that didn't get muh vaccination shots that don't work because muh vaccination shots that don't work don't work."

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Wednesday, September 1, 2021 3:24 AM


Fear-mongering among the anti-COVID-vax crowd.


https://www.theepochtimes.com/whos-really-being-hospitalized_3963392.h
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A lot of it depends on really intentionally misleading reporting.

Quote:

“We don’t have accurate numbers,” insists Dr. James Neuenschwander, an expert on vaccine safety based in Ann Arbor, Michigan.
But what we do know, Neuenschwander says, is that the vaccines are not as effective as public health officials told us they would be. “This is a product that’s not doing what it’s supposed to do. It’s supposed to stop transmission of this virus and it’s not doing that.”

Neuenschwander may call himself an expert. The Epoch Times may refer to him as an expert. But he's a true anti-vaxer with a product to plug (his 'services') as the founder of a company "Bio Energy Medical Center, a multidisciplinary, integrative medical practice located in Ann Arbor, MI".

And he DEFINITELY spouts lies: “This is a product that’s not doing what it’s supposed to do. It’s supposed to stop transmission of this virus and it’s not doing that.”

Well - no. Not at all.
As I've already pointed out at least a couple dozen times, the vaccines were developed to reduce severe COVID-19 and deaths. That was the endpoint of ALL studies done on vaccine effectiveness. The researchers and the companies knew that because this was an injected vaccine, it wouldn't stimulate mucosal IgA antibodies, and it's at mucosal surfaces where infection and transmission occur. That the vaccines happened to reduce transmission of the original strain of SARS-CoV-2 was an unexpected (and afaik still unexplained) benefit - but that was never, ever, even remotely-hinted-at, the goal of the vaccines. To repeat, the formal measures to determine if a vaccine was good or not were severe illnesses and deaths, not 'transmission', as Neuenschwander falsely claims.

When it comes to 'wrong COVID-19 numbers' the article points to extremely rare misreporting by doctors and medical examiners, without being able to show that these are widespread systematic issues.

In another instance "... nursing home officials said their (COVID-19) data were somehow scrambled, either because nursing home personnel reported in the wrong columns, or the numbers were loaded incorrectly somewhere between the CDC and CMS." https://www.medpagetoday.com/infectiousdisease/covid19/86967 But database data transfers are notoriously easy to corrupt. All it takes is a missing, or extra, comma (or other field delimiter) to scramble everything else that comes after that in the data stream. So column 4 may be reported as column 5, 5 as 6, ... and so on, all they way down in every column to column 87.

And while people make a big stink about individual data streams being accidentally over-reported (and which is in the process of correction), nobody seems to admit that there's the opposite problem - data being very much underreported (unless of course it's NYS and political hay is to be made!).


What do I make of all the misleading reporting out there? It sure seems to be intentional.

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Wednesday, September 1, 2021 4:48 AM


General thoughts on 'what is disease' ...

If a tree falls in the forest, and there's nobody around to hear, does it make a sound? Or, if a medical abnormality has no obvious symptoms, does it exist?

To some extent the answer depends on your life philosophy. If you think that the only thing that exists is what you sense, then you'll answer no to both those questions (and if you close your eyes and plug your ears to the big truck coming at you, you'll be saved). But if like me you believe that there's an objective reality that exists without personal perception, then the answers will be yes.

So one big problem - if you believe in an objective reality - is the false equation between symptoms and disease.

I know of a LOT of diseases that can exist over many, many years without any symptoms at all, that won't alert you of their presence until right before you die. Lung cancer, ovarian cancer, and pancreatic cancer are notoriously cryptic until just before they kill you. Does that mean those cancers didn't exist at all until you developed symptoms ... and then died?

OTOH there can be many causes for the same symptoms. For example a left big toe could be red, swollen, and painful due to infection, gout, or a broken bone. But all those symptoms are clustered together. Does that mean that there's a "red, swollen, and painful left big toe disease"?
No. The observation that there are many obvious and completely distinguishable causes for a red, swollen, and painful left big toe is the reason why there's no listed disease as "red, swollen, and painful left big toe disease". Instead, diseases are grouped according to a common precipitating cause of the symptoms - like a broken bone.

Even more, 2 people with the exact same medical problem can show non-identical clusters of symptoms. Asthma can exist with and without wheeze, for example, even though both will show impaired exhalation on testing.

(BTW, I know of no one who runs their real life with the notion that 'if you don't sense it, it doesn't exist'. They know that even if they can't see water damage behind the walls, if there's a leak, it still exists. Or that if they don't check their car's engine oil, running too low for too long will still cause engine damage.)

Because many even fatal diseases can exist without symptoms; many different causes can create the exact same symptoms; and people with the same disease can have a different mix of symptoms; it's important to understand that there's a correlation between symptoms and disease; but that it's necessary to distinguish one from the other. A disease can exist without symptoms, or with a variable cluster of symptoms, and not all symptoms have the same cause. in other words, disease does not equal symptoms. Again - a lack of symptoms doesn't mean you're free from disease, a cluster of symptoms doesn't mean you have what your neighbor with the same symptoms has, and having the same disease doesn't mean you'll all have the same symptoms.


Moving on to infections in general, and COVID-19 in particular.

In general, there are many different symptoms associated with 'infections': localized infection is associated with heat, redness, and tissue swelling, for example; and more generalized infections are associated with fever, higher heart rate, malaise, and headache, for example.

And in both types of infection it's not the antibodies that cause those symptoms, it's your own body's high level of cytokines doing that. Cytokines are completely different than and distinguishable from antibodies. Among other things cytokines help in commanding your body's responses to infection, from calling immune cells en masse, to creating body-wide responses far from the infection site, like fever.

And when your body's cytokines go overboard, the generalized old-fashioned name for it is 'cytokine s

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Wednesday, September 1, 2021 1:00 PM

Thank you for the post, KIKI.



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Pity would be no more,
If we did not MAKE men poor - William Blake

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Wednesday, September 1, 2021 1:27 PM

Quote:

Originally posted by 1KIKI:

So what's going on with Israel?

Israel has 3 extremely sharp COVID-19 peaks so far.

6276 cases/ 7 days Sep 27 2020
39 deaths / 7 days Oct 15 2020
CFR 0.62

8190 cases/ 7 days Jan 15 2021
65 deaths / 7 days Jan 25 2021
CFR 0.79

6991 cases/ 7 days Aug 21 2021
5923 cases/ 7 days Aug 9 2021
21 deaths / 7 days Aug 21 2021
CFR 0.35

Pfizer mass vaccination: Jan 1 - March 31 2021
Most eligible people were vaccinated 5-8 months ago, reaching a peak for the first vaccination wave of 57% of the total population.

Israel's vax eligibility age limit was 16, and about 25% of its population is under 16. So about 25% are unvaxed due to age, and by calculation about 18% are eligible unvaxed. So current cases are probably skewed to the young; and deaths have a 'youth discount'.

With that in mind, the current CFR at roughly half the previous CFR may be in part due to an age discount and not vaccination status.

Obviously these are 'back of the envelope' calculations; I'm sure the Israeli government has exact figures.

That might be why Israel is giving out booster shots. Vax effectiveness against death isn't as robust as they supposed.

I usually go to Divoc-91 to look at the curves, but I AM confused about what they call "cases". What does it mean?

It's not "hospitlaizations" because THOSE are reported separately. So does it mean "reported to a doctor"? Or "Confirmed infections"? I'm under the impression that - for Divoc-1- it means "confirmed infections", whether the person is symptomatic or not. And the reason why I think that is how Divoc-91 is using the term bc their "new cases" is highly dependent on the number of tests being administered.

Anyway, according to Divoc-91, Israel is experiencing its highest #of (new) confirmed cases, ever. Their previous high (one wk avg) was 94 per 100,000 on January 17, 2021. Their CURRENT high (as of this date) is 97 per 100,000. I haven't done a first, second, and third derivative on the data (useful for peak detection) but just visually the peak shows no signs of heeling over.

Their previous peak deaths was 0.71 per 100,000 (Jan 25) and their current death rate topped out at 0.29 per 100,000 and the last point was lower than the previous, so one hopes the death rate has topped out.

132 'cases' per death during the previous peak versus 334 'cases' per death now (however Divoc-91 defines 'cases') Or, put another way a CFR of 0.76% previously and 0.30% now, keeping in mind that 'death' may not have caught up to 'cases' yet.

So I'm getting about the same figure as you: a CFR about half of previous. That's good news.

Much more serious than a common cold. I'm sure the Israeli Ministry of Health is keeping a close eye on the CFR of the vaccinated elderly versus the unvaccinated young.

However, according to the Mayo study (roughly 33,000 people in each "arm" of the Pfizer/BNT v Moderna v unvax) all of the deaths, except one, occurred in the unvax cohort. Now, the Mayo population was vaccinated much later than the Israeli population, and it seems the vax effectiveness drops off precipititously, which is prolly why Israel is going with booster shots.

-----------
Pity would be no more,
If we did not MAKE men poor - William Blake

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Wednesday, September 1, 2021 1:58 PM

Quote:

The good news is that among Israel's serious infections on Thursday of this week, according to Health Ministry data, the rate of serious cases among unvaccinated people over age 60 (178.7 per 100,000) was nine times more than the rate among fully vaccinated people of the same age category, and the rate of serious cases among unvaccinated people in the under-60 crowd (3.2 per 100,000) was a little more than double the rate among vaccinated people in that age bracket.


So if you've over 60 and haven't been vaccinated, your risk of serious illness is almost 10X that of a fully-vaccinated person. And if you're under 60 and haven't been vaccinated, your risk of serious illness is almost double that of a vaccinated person.

Quote:

Israel is the first country to offer a third shot of the Pfizer vaccine in a nationwide booster campaign. Preliminary research in Israel suggests booster shots significantly increase protection against the coronavirus a week after a person receives the third dose.

Israeli national HMO Maccabi Healthcare Services, which conducted the preliminary study of 149,144 Israelis who received three Pfizer shots, said for Israelis above age 60, a Pfizer booster shot reduced the chances of infection by 86% and reduced the chances of severe infection by 92%.



https://www.npr.org/sections/goatsandsoda/2021/08/20/1029628471/highly
-vaccinated-israel-is-seeing-a-dramatic-surge-in-new-covid-cases-heres-why


If I have time I'll try to find the original study.



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Pity would be no more,
If we did not MAKE men poor - William Blake

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Friday, September 3, 2021 5:19 PM

I decided to look up Covid-19 and cytokine storm, which appears to trigger the most fatal consequence of Covid-19 infection: Acute Respiratory Distress Syndrome (ARDS)

It is ARDS that causes most deaths, but some studies show heart endothelial damage as well.

Cytokine storm from Covid-19 appears to be triggered by reaction to the spike protein. In trangenic mice which express humanized ACE docking sites, a subunit of the spike protein (S1) appears to trigger cytokine reaction, but - curiously- the entire (whole) spike protein does NOT seem to cause the same response. [my guess- because the S1 subunit is normally folded into the interior of the spike protein)
https://pubmed.ncbi.nlm.nih.gov/34156871/

Here is a comprehensive description of the various monoclonal antibody studies targeting spike proteins, spike protein receptors, interleukins, and marcrophages either with EUA or in trial for pre- or post-exposure prophylaxis, or for treatment of ARDS and other serious cases of Covid-19.

I thought this was particularly interesting

Quote:

After binding of SARS-CoV-2 to alveolar epithelial cells, production of a range of proinflammatory cytokines and chemokines, including GM-CSF and IL-6 occur, which in turn recruit more monocytes and macrophages and lead to a subsequent cytokine storm [21]. A great number of studies showed a raised level of various cytokines and chemokines including IL-2, IL-6, IL-7, IL-10, IL-17, G-CSF, GM-CSF, IP-10, MCP1, MIP1A, TNFa, IFN-?, VEGF, CCL2, etc. in more severe patients with COVID-19.

Although complete characteristics of cytokine storm in COVID-19 are yet to be specified, anti-cytokine mAb could play a crucial role in the case of severe COVID. Multiple IL-6 inhibitors including tocilizumab (phase 4), sarilumab (phase 3), and siltuximab are currently under investigation in clinical trials in several concerned groups. Among them, tocilizumab showed immediate improvement in the clinical outcomes of severe and critical patients, which proved to be an effective treatment for reducing mortality ...

A case-control study showed 80% reduction in relative risk of invasive ventilation and/or death in patients treated with lenzilumab [targets granulocyte macrophage colony-stimulating factor GM-CSF] compared with the control group [30]. In addition, the median time to resolution of ARDS reduced to one day along with early discharge from the hospital for patients treated with lenzilumab versus eight days to resolution...

A study conducted on 10 terminally ill COVID-19 patients observed complete CCR5 receptor occupancy by leronlimab (CCR5 antagonist) on macrophage and T cells, resulting in a rapid reduction of plasma IL-6, restoration of the CD4/CD8 ratio, and a significant decrease in SARS-CoV-2 plasma viremia [32]. A novel approach using leronlimab thus could play an important role in resolving unchecked inflammation, restoring immunologic deficiencies, and reducing SARS-CoV-2 plasma viral load via disruption of the CCL5-CCR5 axis



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872849

So research is ongoing to blunt the various aspects of cytokine storm which is fatal for some people.

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Pity would be no more,
If we did not MAKE men poor - William Blake

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Friday, September 3, 2021 5:45 PM

Here is a recent WHO study (april 2021) of the effectiveness of remdesivir, hydroxychloroquine, lopinavir, and interferon on crtically ill patients.

I noticed that ivermectin was not included in the study. And the caveat to HCQ still applies- to be used as prophylaxis, not treatment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872849/

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Pity would be no more,
If we did not MAKE men poor - William Blake

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Saturday, September 4, 2021 6:27 AM

General info on cytokines and chemokines

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211650/

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Pity would be no more,
If we did not MAKE men poor - William Blake

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Saturday, September 4, 2021 6:37 AM

Communal mask wearing had zero effect on subjects under the age of 50. The entire effect is for those 50 and older. That deserves a whole lot of attention since it's such an unexpected result.

https://jabberwocking.com/new-study-says-masks-work-if-youre-over-50/

The Joss Whedon script for Serenity, where Wash lives, is Serenity-190pages.pdf at https://www.mediafire.com/two

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